The DEEP project has received research funding from the European Union under the 7th Framework Programme

DEEP-2 study: the final results are available on EudraCT

DEEP-2 study: the final results are available on EudraCT

7 Gennaio, 2020
|
Comments off
|

We are glad to announce that the DEEP-2 study Phase III multicentre, randomised, open label, non-inferiority active-controlled trial aimed at comparing for the first time the efficacy of deferiprone (DFP) versus deferasirox (DFX) in paediatric patients aged from 1 month to less than 18 years, affected by hereditary haemoglobinopathies has terminated and the results are available on EudraCT Database and at this link.  Included in the DEEP (DEferiprone Evaluation in Paediatrics) project (FP7 GA n. 261483), DEEP-2 trial involved 393 patients recruited in 23 clinical centres in 7 EU and non-EU countries: Albania (2), Cyprus (1), Greece (1), Egypt (3), Italy (12), Tunisia (1), UK (3).

In particular, the study intended to investigate the changes in terms of ferritin levels and cardiac iron concentration in order to assess the non-inferiority of deferiprone compared to deferasirox in paediatric patients affected by hereditary haemoglobinopaties requiring chronic transfusions and chelation. Overall, the study provided evidence to support the use of DFP in paediatric patients.

Share